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Research

Psychoneuroimmunology is an emerging field of research with promising results. This page contains publicly available, peer-reviewed research for interested parties to learn more. PNI Therapeutics is an active contributor to research and collaborates with health sites to study the efficacy of Virtual Reality therapeutics.

Virtual Reality in Cancer Care and Healthcare 

2019

Zeng, Yingchun, et al. “Meta-Analysis of the Efficacy of Virtual Reality–Based Interventions in Cancer- Related Symptom Management. Integrative Cancer Therapies, vol. 18, 2019, p. 153473541987110., doi:10.1177/1534735419871108.

2022

Buche H, Michel A and Blanc N (2022), Use of virtual reality in oncology: From the state of the art to an integrative model. Front. Virtual Real. 3:894162. doi: 10.3389/frvir.2022.894162

2023

Franklin DM, Silvestro C, Carrillo RA, Yang Y, Annadurai D, Ganesan S, Vasantham DSJ, Mettu S, Patel M, Patil MS and Akurathi ND (2023) The impact of meditation aided by VR technology as an emerging therapeutic to ease cancer related anxiety, stress, and fatigue. Front. Virtual Real. 4:1195196. doi: 10.3389/frvir.2023.1195196

2015

Chirico, Andrea & Lucidi, Fabio & De Laurentiis, Michele & Milanese, Carla & Napoli, Alessandro & Giordano, Antonio. (2015). Virtual Reality in Health System: Beyond Entertainment. A Mini-Review on the Efficacy of VR During Cancer Treatment. Journal of cellular physiology. 231. 10.1002/jcp.25117.

2020

Chirico, Andrea & Maiorano, Patrizia & Indovina, Paola & Milanese, Carla & Giordano, Giovan & Alivernini, Fabio & Iodice, Giovanni & Gallo, Luigi & De Pietro, Giuseppe & Lucidi, Fabio & Botti, Gerardo & De Laurentiis, Michele & Giordano, Antonio. (2020). Virtual reality and music therapy as distraction interventions to alleviate anxiety and improve mood states in breast cancer patients during chemotherapy. Journal of Cellular Physiology. 235. 10.1002/jcp.29422.

2021

Koren, Tamar & Yifa, Re’ee & Amer, Mariam & Krot, Maria & Boshnak, Nadia & Ben
Schneider, Susan & Hood, Linda & Ellis, Mathew & Lipkus, Isaac & Landerman, Lawrence. (2021). Virtual Reality Intervention for Chemotherapy Symptoms.

2023

Erdős, Sándor & Horváth, Klára. (2023). The Impact of Virtual Reality (VR) on Psychological and Physiological Variables in Children Receiving Chemotherapy: A Pilot Cross-Over Study. Integrative cancer therapies. 22. 15347354231168984. 10.1177/15347354231168984.

2021

Tennant M, Anderson N, Youssef GJ, McMillan L, Thorson R, Wheeler G, McCarthy MC. Effects of immersive virtual reality exposure in preparing pediatric oncology patients for radiation therapy. Tech Innov Patient Support Radiat Oncol. 2021 Jul 8;19:18-25. doi: 10.1016/j.tipsro.2021.06.001. PMID: 34286115; PMCID: PMC8274338.

2022

Addab S, Hamdy R, Thorstad K, Le May S, Tsimicalis A. Use of virtual reality in managing pediatric procedural pain and anxiety: An integrative literature review. J Clin Nurs. 2022 Nov;31(21-22):3032-3059. doi: 10.1111/jocn.16217. Epub 2022 Jan 23. PMID: 35068011. [abstract only]

2020

Tennant M, McGillivray J, Youssef GJ, McCarthy MC, Clark TJ. Feasibility, Acceptability, and Clinical Implementation of an Immersive Virtual Reality Intervention to Address Psychological Well-Being in Children and Adolescents with Cancer. J Pediatr Oncol Nurs. 2020 Jul/Aug;37(4):265-277. doi: 10.1177/1043454220917859. PMID: 32536320. [abstract only]

2019

Snoswell, Aaron & Snoswell, Centaine. (2019). Immersive Virtual Reality in HealthCare: Systematic Review of Technology and Disease States. JMIR Biomedical Engineering. 4. e15025. 10.2196/15025.

2019

Pizzoli, Silvia & Mazzocco, Ketti & Triberti, Stefano & Monzani, Dario & Alcañiz Raya, Mariano & Pravettoni, Gabriella. (2019). User-Centered Virtual Reality for Promoting Relaxation: An Innovative Approach. Frontiers in Psychology. 10. 10.3389/fpsyg.2019.00479.

Psychoneuroimmunology, Complementary & Alternative Medicine for Cancer, Placebo Effect

2016

Yan, Qing. “Psychoneuroimmunology and Cancer.” Psychoneuroimmunology, 2016, pp. 97–108., doi:10.1007/978-3-319-45111-4_11.

2013

Messina, Giuseppina, et al. “Psychoimmunological Analysis of Cancer Patients: Correlation with the Prognosis.” Current Aging Science, vol. 5, no. 3, 2013, pp. 263–272., doi:10.2174/1874609811205030014.

2002

Kiecolt-Glaser, Janice K., et al. “Psychoneuroimmunology: Psychological Influences on Immune Function and Health.” Journal of Consulting and Clinical Psychology, vol. 70, no. 3, 2002, pp. 537–547., doi:10.1037/0022-006x.70.3.537.

2002

Kiecolt-Glaser, Janice K., et al. “Emotions, Morbidity, and Mortality: New Perspectives from Psychoneuroimmunology.” Annual Review of Psychology, vol. 53, no. 1, 2002, pp. 83–107., doi:10.1146/annurev.psych.53.100901.135217.

2016

Conley, Claire & Bishop, Brenden & Andersen, Barbara. (2016). Emotions and Emotion Regulation in Breast Cancer Survivorship. Healthcare. 4. 56. 10.3390/healthcare4030056.

2021

Shaanan, Tamar & Azulay-Debby, Hilla Zalayat, Itay & Avishai, Eden & Hajjo, Haitham & Schiller, Maya & Haykin, Hedva & Korin, Ben & Farfara, Dorit & Hakim, Fahed & Kobiler, Oren & Rosenblum, Kobi & Rolls, Asya. (2021). Insular cortex neurons encode and retrieve specific immune responses. Cell. 184. 10.1016/j.cell.2021.10.013.

2018

Hoenemeyer TW, Kaptchuk TJ, Mehta TS, Fontaine KR. Open-Label Placebo Treatment for Cancer-Related Fatigue: A Randomized-Controlled Clinical Trial. Sci Rep. 2018 Feb 9;8(1):2784. doi: 10.1038/s41598-018-20993-y. PMID: 29426869; PMCID: PMC5807541.

2018

Zion, Sean R., and Alia J. Crum. “Mindsets Matter: A New Framework for Harnessing the Placebo Effect in Modern Medicine.” International Review of Neurobiology. Neurobiology of the Placebo Effect Part I, 2018, pp. 137–160., doi:10.1016/bs.irn.2018.02.002

2005

Kronenberg, Fredi, et al. “The Future of Complementary and Alternative Medicine for Cancer.” Cancer Investigation, vol. 23, no. 5, 2005, pp. 420–426., doi:10.1081/cnv-200067159.

2009

Eremin, Oleg, et al. “Immuno-Modulatory Effects of Relaxation Training and Guided Imagery in Women with Locally Advanced Breast Cancer Undergoing Multimodality Therapy: A Randomised Controlled Trial.” The Breast, vol. 18, no. 1, 2009, pp. 17–25., doi:10.1016/j.breast.2008.09.002.

2015

Jim, Heather & Pustejovsky, James & Park, Crystal & Danhauer, Suzanne & Sherman, Allen & Fitchett, George & Merluzzi, Thomas & Munoz, Alexis & George, Login & Snyder, Mallory & Salsman, John. (2015). Religion, Spirituality, and Physical Health in Cancer Patients: A Meta-Analysis. Cancer. 121. 10.1002/cncr.29353.

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